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En la presente invención se describen diterpenos capaces de modular la expresión de los componentes de la matriz extracelular en fibroblastos de la dermis humana. Once diterpenos de neo-clerodano se aislaron y su estructura se determinó por técnicas espectroscópicas y espectrométricas; incluyendo su configuración absoluta por análisis de difracción de rayos-X. La invención se relaciona además a los extractos y/o fracciones estandarizadas de dichos compuestos aislados de los mismos, con actividad cicatrizante, útiles como agentes en composiciones dermofarmacéuticas y cosméticas.
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